Chapter 210: Capital Flow (Requesting Subscription)

"Senior Brother, you wouldn't be planning to establish a new animal model yourself, would you?" Luo Tingzhu, chatting with Fang Ziye, keenly caught Fang Ziye probing the direction, her typing still carrying disbelief.

Medical research can roughly be divided into three major areas: clinical research, cell experiments, and animal experiments.

The subjects of clinical research are patients, the subjects of cell experiments are cell lines, and the subjects of animal experiments are animal models or 'animal lines' corresponding to cell lines.

In cell experiments, some tumor cells, inflammatory cells, can be passaged and cultured.

But during animal testing, any special type of animal has no such thing as passage.

One animal, after the experiment, even if it has offspring, cannot be equal to it, nor even similar.

Therefore, animal experiment models are in high demand and belong to one-time demand raw materials used repeatedly.

Establishing a new animal model initially appears as part of basic animal experiment composition, a sub-experiment of someone else's research group, but once successful, after a relatively complete model processing is stripped out, the value and benefits brought are enormous.

And establishing a new animal model is the cutting edge and ceiling level of current animal experiment research directions, equivalent to discovering a new pathway in cell pathways and naming a new research gene, both being among the most top-tier operations worldwide.

The operational difficulty and research funds consumed are both enormous.

"My teacher once taught me that a person must have dreams, otherwise, for clinical doctors like us, the meaning of doing research would be absolutely dismissed, just seeking fame and profit for promotion and title."

"But what if?"

Fang Ziye replied seriously in his rental house: "In our Eastern Han, for example, those hematology teachers at Ruijin Hospital, if not driven by the dream of being able to treat leukemia, a type of blood cancer, they definitely could not have developed corresponding drugs, nor supported the cutting-edge drugs of blood treatment."

"To reach this step, mastering the skill of walking ahead of time is very crucial."

Fang Ziye did not boast in front of Luo Tingzhu, just telling the truth.

Fang Ziye could not confirm whether he could take a detour to intercept a car midway; while everyone else was connecting hk2 and tumors, he directly made the animal experiment where hk2 was knocked out and could still survive.

The correlation between hk2 and tumor treatment definitely requires answering the first question: after hk2 is knocked out, will normal people die, can normal mice survive.

This question is the guarantee of everything.

If, after knocking out the hk2 gene, the mice die, then this pathway should not be researched further.

If even mice die, who dares to do research on humans further?

The in-depth research of this route would be urgently stopped, and Fang Ziye's direction still belongs to ultra-high-end cutting-edge, equivalent to an emergency stop button for research institutions worldwide.

But if Fang Ziye happens to have a stroke of luck or a fortunate coincidence, creates the mouse model with hk2 knocked out, and it is still alive, then it will further deepen the significance of this hk2 pathway for tumor treatment.

And not just the research between hk2 and osteosarcoma cannot bypass Fang Ziye; any other tumor, as long as the research direction is related to the hk2 pathway, then you absolutely cannot bypass Fang Ziye Team.

This is beyond doubt!

Such a detour overtaking belongs to one of the few shortcuts in the research field.

But to take such a shortcut, the difficulty is no less than the probability of an undergraduate being directly promoted to professor.

Although the probability of an undergraduate being directly promoted to professor on the spot is not high, it exists.

Similarly, similar things have also happened in the research field. It's just that such cases are mostly abroad, so few people domestically are familiar with them, and even foreigners, unless they are in the same country, will not widely publicize geniuses from other countries.

Research has no nationality, but scientists have nationality.

Talent also has nationality.

Just as Fang Ziye would not pay too much attention to which terrifying geniuses Jingdu University's affiliated hospitals or Peking Union Medical College Hospital have had in recent years, others also cannot be bothered to care about what talents with decent qualifications Zhongnan Hospital has.

It's just those from the same hospital, same department, acquaintances, familiar people, will pay a little attention.

Everyone's energy is relatively limited.

Luo Tingzhu said: "Hmm, Senior Brother, the general method is just these; to complete a complete knockout of nude mouse genes, there will be very many steps."

"Its operational difficulty is at least equal to the new gene sequencing you previously explored with Senior Brothers from Associate Professor Hong Zili's group, and the probability of operational accuracy is also about the same."

"But Senior Brother, you go for it; if you happen to succeed."

"Then?"

"Then then then." Luo Tingzhu couldn't get it out.

The example Fang Ziye brought up, Luo Tingzhu, as a medical student, and as a clinical medicine student, knew it was an example written in textbooks.

Academician Wang of Ruijin Hospital affiliated with Magic Capital Jiaotong University researched all-trans retinoic acid for the treatment of acute promyelocytic leukemia, creating a miracle of four academicians, and also won the National Highest Science and Technology Award!

This is no joke.

Although establishing a new animal experiment model has lower clinical significance than directly treating leukemia, its research significance is at least one-third to one-quarter.

"Then what then, the eight characters haven't even one stroke, we don't dream, nor draw cakes."

"Honestly first familiarize yourself with the method; Associate Professor Hong Zili spends money with dreams, our small team, if we want to climb up, we must do some not-so-conventional things."

"Ordinary relationships between pathways and tumors are just verification experiments; actually, the relationships between these pathways and other tumors have long been done by others."

"Not possessing absolute originality!"

"Oh, right, don't tell others, lest you be lifted too high, and lest people say you aim too high." Fang Ziye instructed Luo Tingzhu.

Fang Ziye is currently just a graduate student who has not yet entered the doctoral program, yet he says he wants to do such an ultra-high-difficulty research project, inevitably people will say he wants to become famous and has gone crazy.

What Fang Ziye wants to do is to do it silently; either silently fail, or become famous overnight.

"Not tell Master either?" Luo Tingzhu certainly wouldn't spread it, but she felt that if Fang Ziye had such an idea, he definitely needs Teacher Deng to get money.

Fang Ziye currently has only million-level research funds; to do such a project is no different from holding twenty thousand yuan to buy a house in Han City, the gap might be hundreds of times.

"Try it first; if there are results later, continue to the next step; if not, stop it; I also dare to spend at most two or three hundred thousand, how dare I use it all?"

"Master doesn't easily get research funds; biotechnology companies definitely like to see us rushing forward recklessly. Money must still be spent on the blade's edge."

"Junior Sister, you also help me pay attention and ask; if there are some small tricks, tell me, but also be careful not to leak the secrets of the research group you are currently in."

"As for specific pathways, key experimental steps, or unfamiliar reagents, it's better not to leak secrets; these are your laboratory's things; if you tell me and it's found out, you won't be able to stay there." What Fang Ziye needs is for Luo Tingzhu to inquire for him about common, already public and transparent methodologies.

Rather than stealing other research results.

What is methodology? It is how this experiment is done; are there some operational methods and skills unrelated to reagents, instruments unique to the laboratory, etc.

"Okay, Senior Brother."

"I have been paying attention, actually I..." Luo Tingzhu sent a smile emoji, hesitating to speak.

"Actually you sometimes think about such shortcuts, right? What's there to be embarrassed about? I still hope I can discover an absolute targeted drug for treating osteosarcoma tomorrow!" Fang Ziye said with a smile.

"Hmm, that is, I admit."

"But we should also stand on reality."

"Senior Brother, our research project group, in establishing new animal experiment models, has already consumed six million US dollars so far, without obtaining concrete results; in gene sequencing, we have spent absolutely twenty million dollars, without any particularly substantive research progress."

"So, how about we just make a small fuss and act within our means?" Luo Tingzhu advised Fang Ziye in subtle speech.

"I know, actually I'm also very poor. The research project group's money is never enough." Fang Ziye replied, then said: "Tian Luo is looking for me, how about we chat later?"

"Has he looked for you?"

Fang Ziye interjected, regarding Luo Tingzhu's private matter, but Luo Tingzhu first fell silent for a moment, then replied: "I didn't let him look for me."

"Then you rest first. My takeout is almost here." Fang Ziye saw that the time on his side had already reached twelve-thirty noon, and thus ended the chat.

"Senior Brother, you also pay attention to rest, good afternoon." Luo Tingzhu's chat enthusiasm seemed to be instantly disrupted by Fang Ziye.

"Good night." Fang Ziye replied.

Just as he finished replying, Fang Ziye's phone call came: "Just leave it at the doorway later, no need to knock."

……

"Senior Brother, I received several invoice slips on my side; a sales representative from a gene company said this is an invoice for things you bought, but the things haven't arrived at the laboratory, yet were signed for."

"Is this real, or a joke? Senior Brother Jie asked me first." Lan Tianluo asked.

"Yes, Tian Luo, you confirm the signature receipt." Fang Ziye replied.

"But, Senior Brother, our animal experiments aren't already completed? My Master, Senior Brother, and several others have already finished collecting all the animal experiment data?" Lan Tianluo replied, then returned a doubtful head-scratching expression.

"This is a secret, let's not talk about it for now."

"How is your model data analysis going? If it's too troublesome, delegate some of the tasks, spend some money." Fang Ziye asked.

(Chapter End)