Chapter 815

"President Zhang, President Yuan, why have the two of you specially come to see me? It makes me a bit flattered." Fang Ziye smiled lightly.

Han City University has many colleges; the Medical College and Affiliated Hospital are not its strong suits, and to some extent actually drag the school down.

Although Fang Ziye is developing quite well in the medical circle now, it still doesn't warrant President Zhang Pingwen personally paying attention to him and making an "inspection"!

In the school, there are no small number of people holding research projects bigger and more important than Fang Ziye's, and there are even some classified projects.

Yuan Yufeng replied: "President Zhang has always paid attention to our Medical College and Clinical College; the development of the Medical College and Clinical Hospital has also always been a direction our school's development leans toward."

"President Zhang, this Professor Fang Ziye can be said to be the standout among our school's three clinical colleges; previously he was even exceptionally promoted by the National Health Commission to Associate Professor and Deputy Chief Physician..."

Upon hearing this, Zhang Pingwen raised his hand slightly, signaling Yuan Yufeng to stop the introduction: "Professor Fang, I know you're busy too, so I won't beat around the bush."

"Actually, the day before yesterday I received a research call from above about you; yesterday I was delayed by something, so only today did I think I must come find you."

"This kind of thing is still better asked clearly face-to-face."

"Is the project planning document you privately passed to the National Natural Science Foundation of China Committee real or fake?"

"This matter is no small matter."

After speaking, Zhang Pingwen deliberately took a document out of his briefcase—

"Our country's generic drug industry is large but not strong, with insufficient innovation capability, and moreover, there are almost no generic targeted drugs in our Eastern Han market, unable to form competition, so targeted drug prices naturally cannot come down."

"Because early-approved generic drugs had relatively weak pharmaceutical research foundations, some generic drugs have a large gap in quality compared to the reference drugs, and still cannot achieve the clinical effects of the reference drugs."

"To improve generic drug quality, our country issued the 'Generic Drug Quality Consistency Evaluation Work Plan (Draft for Comment)', proposing to complete quality consistency evaluation for some varieties by 2014, basically complete quality consistency evaluation for all solid oral preparations by 2015, and carry out quality consistency evaluation for injections and other dosage forms from 2015 to 2020..."

After Zhang Pingwen handed the document to Fang Ziye, he took out another document.

On it was news content released by Xinhua Net—

Generic drugs entering the domestic hospital centralized procurement system all need to pass the National Medical Products Administration's "consistency evaluation."

Theoretically, passed-evaluation drugs should not differ much from original drugs in bioequivalence. However, bioequivalence does not represent clinical equivalence; from clinical feedback, some passed-evaluation drugs still have differences from original drugs in absorption, efficacy, and other aspects.

Drug crystal form is the crystal structure formed by drug molecules arranging in a certain pattern in the solid state.

Different crystal forms of the same drug may have significant differences in appearance, solubility, melting point, dissolution rate, bioavailability, and other aspects, thereby affecting the drug's stability, bioavailability, and therapeutic effect.

... some generic drugs with slightly poorer absorption and utilization can achieve the same therapeutic effect by increasing the dose, but the absorption curve will differ from the original drug.

The quality standard of the reference original drug that generics benchmark against is a range indicator; for example, 95%-105% are all qualified. The original drug may achieve 102%, domestic pharma companies may achieve 97%, both are reasonable differences, but the reasonable differences from each item accumulate across multiple items, and the gap becomes larger and larger.

If ten years ago (before the consistency evaluation system was implemented) most domestic generic drug companies could only score 20 points, a few could reach 60 points, then after the consistency evaluation system was implemented, the vast majority of companies can reach above 60 points, and there are hundreds of companies at 80-90 points.

After Zhang Pingwen circled the important content, he said: "Professor Fang, you are a doctor, you should know that with drugs, 95 points and 100 points also have an enormous difference!"

"And you? In the project bid document submitted to the National Natural Science Foundation of China Committee, the description speaks of clinical therapeutic efficacy, not bioequivalence."

Bioequivalence is animal testing; clinical efficacy is evaluating the actual effect after real patients use it.

Fang Ziye nodded, but his tone was very surprised: "President Zhang, my project bid document could even be passed to you?"

Fang Ziye's current scientific research achievements and the projects he is pushing in medicine are still quite "energetic"; last year the National Natural Science Foundation of China Committee specially went to Enshi to register and approve Fang Ziye's research projects.

Afterwards they naturally gave Fang Ziye some special "privileges," such as when there are important projects, he can contact them anytime.

The Natural Science Foundation Committee has a dedicated Medical Specialty Office; they also need performance, and want to invest money in clinical research workers more capable of producing results.

Zhang Pingwen was very puzzled: "Professor Fang, if you have this kind of capability, why don't you go do innovative drugs? Why must you wade into this muddy water of generic drugs?"

"This would scatter your energy a lot, right?"

Figuring out how to make generic drugs reach the level of original drugs is not easy.

Generic drugs can make money once produced; don't pharma companies know to think of ways?

It's just that the production processes of brand-name drugs are all trade secrets, fundamentally impossible to publish; only the published crystal forms and preparation modes give you large debugging space, but the trial-and-error rate is also very high.

Wanting to reach seventy or eighty percent efficacy is already not easy!

Fang Ziye certainly wouldn't say that pharmaceutical preparation processes certainly have nothing to do with medicine, but clinical efficacy does.

Fang Ziye possesses the most awesome Level 7 Medical Basic Research divine skill, which can maintain infinite "innovation" capability.

Fang Ziye replied: "President Zhang, there is a concept we must understand: drug content and therapeutic efficacy are not directly related."

"Drug combination, drug conjunction, prescription correction, ratios, etc., are what are most closely related to clinical efficacy."

"Of course, an even more sufficient reason is that generic drugs are simple; there is a ready-made system, take it out and it can be used."

"Besides having no research output, the practical significance is still extremely huge."

Zhang Pingwen wasn't that easy to mislead; his gaze flashed, then he smiled blandly: "Professor Fang, could it be because you didn't agree to go work in Jingdu, so you no longer thought of advancing?"

Even Han City University doesn't have that many candidates who can be nominated for Academician each year!

Zhang Pingwen naturally pays great attention to this.

Even the reasons for a failed evaluation must be carefully observed and weighed.

Since Fang Ziye was reported upward, the feedback coming back would also have dedicated personnel following up.

Fang Ziye said smiling: "President Zhang, that can't be said like that."

"I'm already very good now; there's no talk of what advancement, Han City University can certainly accommodate this Associate Professor who no longer has output, and Zhongnan Hospital can also accommodate this Deputy Chief Physician who can still eat by relying on skill."

"My salary is also okay; I won't starve or freeze."

"Car and house are both there; I'm just a country person, what else is there to strive for?"

Yuan Yufeng listened on the side, not speaking.

He has currently taken the administrative route; wanting to cross that step in the future won't be too easy.

However, if Zhongnan Hospital can produce an Academician, his face also has light.

Zhang Pingwen replied: "The more lightly you put it, the more it represents that Professor Fang you mind."

"You're still young now, the future is still very long, no need to put down anything just because of this..."

"Professor Fang, you now count as half a pillar of Zhongnan Hospital's surgical research field; if you have any difficulties or ideas, you can communicate more with President Yuan."

Fang Ziye shook his head: "No no no, President Zhang, you misunderstood my meaning; I didn't say I would put down anything myself."

"All my research is proceeding normally!"

Fang Ziye spoke up to here, then said: "As it happens, since Principal Zhang brought it up, and Principal Yuan is also here, I really do have some questions I want to discuss together with Principal Zhang and Principal Yuan."

"Currently, some surgeries in our surgical field have a decent degree of specialization, but the speed of sinking down is still too slow."

"Our hospital's routine surgical procedures, to sink down to prefecture-level city hospitals, need at least twenty to thirty years; to sink down further to county hospitals, who knows how much longer that would take."

"Based on this status quo, I have an immature idea: using our Orthopedics Department as a pilot, establish a teaching team to study how to simplify surgical procedures so that more people can learn them and perform them in clinical practice."

"Just like our Trauma Surgery's mangled extremity limb salvage surgery before, our team has some simplification experience; now it can barely be carried out in prefecture-level city hospitals, but such teaching projects can be expanded further……"

Yuan Yufeng has a medical background; although he is a vice-principal, he has not completely detached from clinical practice. Hearing this, he looked slightly surprised: "Professor Fang, you still want to launch such a large-scale teaching project?"

"Do you have that much energy?"

"Principal Zhang came to find you this time to have a good talk about future planning and development, and also to listen to some of our Zhongnan Hospital Surgery's development goals."

Yuan Yufeng was practically stating it outright.

You talk about your spinal cord injury project, you talk about your bone tumors, why bring those up?

Fang Ziye laughed: "Principal Yuan, sparing this bit of energy should still be possible." "The meaning of scientific research lies in solving practical problems; since we have already found what practical problems we face, we should think of ways to solve them."

"My energy is currently limited; besides continuing to develop new disease treatment methods, I only dare think about some generic drug imitation and a small part of surgical procedure simplification teaching projects."

"I feel that if these can all be done well step by step, then it would not betray the trust and favor of the school and hospital, and even the National Health Commission, toward me!"

If a man does not act for himself, heaven and earth will destroy him!

In poverty, cultivate one's own virtue; in success, benefit all under heaven.

The former Fang Ziye was desperately poor, even borrowed money from his fellow disciples, ran everywhere, to earn money for projects, for competitions.

Back then Fang Ziye's capability was average, his level limited; to say he cared about ordinary people across the world would be a joke.

The current Fang Ziye's capability has already reached an incredible realm, wealth preliminarily free, anyway he won't starve; the path he wanted to explore is cut off, the Nobel Prize is unreachable, what can Fang Ziye do?

No way to act for self, then think of acting for others!

Fang Ziye is not that lofty and arrogant, never sets himself up as a benchmark, but has his own unique way of 'lying flat'!

"Principal Zhang, it wouldn't be that the National Natural Science Foundation Committee also killed my project, would it?" Fang Ziye narrowed his eyes and asked.

Zhang Pingwen heard this, somewhat annoyed: "Killed? Who dares kill your project? You've walked right into the gun muzzle now."

"You yourself are a clinical doctor; how big a deficit your medical insurance has, don't you know yourself?"

"Why is the medical system reforming? What is the most fundamental reason? Do you still need me to analyze it for you?"

"Medical insurance finances are severely in deficit, input less than output, so they can only tighten their belts and get by."

"In such an environment, you propose such a project — it's as good as approved; the hat others avoid like the plague, you pick up and wear on your head."

"I came to find you this time to give you a way out; you come with me to Jingdu, take this project proposal back."

Zhang Pingwen's tone was quite rude.

He wasn't looking down on Fang Ziye, thinking Fang Ziye lacked ability; he just felt Fang Ziye was a bit too arrogant and proud.

One failure and you're this dejected?

How old are you?

Not even thirty-five, the road ahead is very long.

Fang Ziye set his mind at ease, shook his head lightly: "Principal Zhang, as long as it wasn't killed, that's good; I thought my thing got killed too."

"Fang… Professor." Zhang Pingwen wanted to speak but stopped.

Yuan Yufeng heard this and said: "Principal Zhang, how about I talk with Fang Ziye alone for a bit?"

"This matter should still be handled cautiously."

Fang Ziye continued: "Principal Yuan, Principal Zhang, you two might as well listen to me say some things?"

Zhang Pingwen heard this, stunned for a moment, then nodded.

……

Half an hour later, Zhang Pingwen and Yuan Yufeng walked out of Fang Ziye's Director's Office with weird expressions, faces showing indescribable "splendor" and "struggle"!

"Principal Zhang, Principal Yuan, I have surgery later, so I won't see you two off far." Fang Ziye smiled and saw them off all the way to the Ward Door, giving proper instructions.

Zhang Pingwen turned his head, expression changing unpredictably again: "Professor Fang, should I say your ambition exceeds the sky, or that you are unique?"

Fang Ziye replied: "Principal Zhang, my former Supervisor once told me this: if a person doesn't even dare to dream, then this life's upper limit will be fixed dead."

"People always have to dare to think a little."

"Mayo also started from a small clinic; the platform I rely on now is not small."

Yuan Yufeng lowered his voice: "All hospitals want to become Mayo, but in the whole world there is only one Mayo."

Zhang Pingwen and Yuan Yufeng both felt their level was low.

Compared to Fang Ziye's ideas, their expectations and planning were too low-grade, too vulgar, too possessed of low-grade taste.

"Before Mayo appeared, no one knew Mayo would become the current Mayo Clinic."

"Teaching projects must be grasped; our Clinical Group, our hospital's own trustworthy medicines must exist."

"Policy must be followed, scientific research must also rush forward!" Fang Ziye said.

"Other things, if they exist they're icing on the cake; even if they don't, it doesn't matter."

"I'm young anyway, not afraid of embarrassment; even if I don't achieve it later, it's just being labeled 'young and vigorous'; I'm only thirty-two now."

"Right? Principal Zhang?" Fang Ziye laughed shamelessly.

I just said I want to build Zhongnan Hospital into a top-tier existence similar to Mayo Clinic; so what, who dares say someone my age shouldn't say such things?

Elementary school kids still dare dream of becoming scientists and astronauts; you go scold them for being unrealistic!

When a kid acts roguish, it's called open and aboveboard!

Zhang Pingwen and Yuan Yufeng immediately avoided Fang Ziye, directly walked down the stairs.

Fang Ziye did not follow; obviously the two had things to say.

"Principal Zhang, this Fang Ziye's words, you absolutely must not take seriously. He's merely……" Yuan Yufeng said.

Zhang Pingwen glanced at Yuan Yufeng: "Why can't it be taken seriously? Just because he himself feels his words are innocent child's talk, does that really count as innocent child's talk?"

"Investing in an Associate Professor, does it really need so many reasons? The things he wants aren't that many, of course give them to him!!"

"Investment in research funding is nothing but gambling!"

Zhang Pingwen's vision is far broader than Yuan Yufeng's!

Upon hearing this, Yuan Yufeng clicked his tongue incessantly, even feeling whether his brain circuits had rusted, so he couldn't keep up with the times.

"Principal Zhang? You agreed? Weren't you here to persuade Fang Ziye..." Yuan Yufeng asked.

"I originally came to persuade, but now I've been persuaded? What's there to not dare admit?"

"I come to persuade, he must listen, this is an order."

"Fang Ziye's reckless behavior hasn't reached the point of exhausting the people and wasting money, no need for me to issue a ban ordering him not to do things!"

"Dares to think and dares to act, has foundation, has development, has planning, has future, has higher future, has route."

"If even this kind of investment isn't invested, then what the hell investment is still invested?"

"Give it to him." Zhang Pingwen set the tone.

The things Fang Ziye asked the School for weren't many.

Mainly it was one sentence from Fang Ziye that moved Zhang Pingwen!

Is the truly awesome thing about Mayo Clinic that their doctors' operation level is better than Eastern Han's?

Not so!

It's that there are some things that lift up their operations, so possibly in treatment effect, efficacy would be better than Domestic Top Professors.

Among them, including but not limited to equipment, drugs, research accumulation, and basic research cognition, etc.

To do good work, one must first sharpen one's tools!

Yuan Yufeng muttered: "Teaching Project? How to invest in that?"

"Isn't it just making me offend people? Things the School doesn't need to give money for, you Zhang Pingwen can agree in one breath, letting us coordinate internally?"

"Who is willing to easily become a puppet of Fang Ziye's Teaching Project, afterwards only doing clinical technique teaching simplification? Not doing clinical work anymore?"

However, Yuan Yufeng only dared to mutter, not daring to speak these inner thoughts out loud.

As Fang Ziye was about to enter the Operating Room, Research Assistant Han Jingyi said: "Professor Fang, there's a foreign professor in the Email saying they want to visit Han City again, saying they know you, take a look at the information when you have free time..."

(Chapter End)