Fang Han, a former 996 corporate worker, transmigrates into the body of a Chinese medicine doctor participating in the live variety show "Professional Challenge," where the grand prize is one hundred million yuan. The problem is, he knows nothing about medicine—until the Medical God Selection System activates, granting him divine diagnostic abilities and quest-based rewards. Broadcasting from a pharmacy in Jiangcheng, Fang Han stuns viewers by accurately diagnosing patients through pulse-taking, including exposing a terminally ill fraud-blogger who insists his checkups are normal.

As the live audience swings between mockery and awe, Fang Han navigates skeptical Western medicine advocates, rival clinics, and hospital deans while building his reputation and collecting luxury prizes. With each consultation, the audience panics at his uncanny accuracy, and the once-belittled doctor begins to turn the tide for traditional Chinese medicine on national television.